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KMID : 0942820120110020154
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Journal of Korean Brain Tumor Society
2012 Volume.11 No. 2 p.154 ~ p.157
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A Rapid Gliosarcomatous Recurrence of the Glioblastoma
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Song Dae-Hyo
Kim Choong-Hyun
Cheong Jin-Hwan
Kim Jae-Min
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Abstract
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A gliosarcoma represents a biphasic tissue pattern with altering areas displaying glial and mesenchymal differentiation and accounts for approximately 2% of all glioblastomas. We present a rare case with rapid gliosarcomatous recurrence of the glioblastoma which have been taken a complete resection and concomitant chemoradiotheraphy (CCRT). A 54-year-old female presented with sudden onset of the headache. Magnetic resonance (MR) imaging showed a well-demarcated, enhanced lesion in the right fronto-temporal area. She received grossly total tumor resection followed by radiotherapy and chemotherapy. Her postoperative course was uneventful. However, brain MR images at 6 months after surgery demonstrated a newly developed, nodular lesion in the tumor bed. At 9 months after surgery, the follow-up MR images revealed the increased size of tumor in the right fronto-temporo-parietal area with invasion into the right lateral ventricle. She received sur-gery again, and pathological studies revealed a recurrent glioblastoma with the component of gliosarcoma. The authors report and discuss an uncommon case with gliosarcomatous recurrence of glioblastoma after surgery and CCRT.
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KEYWORD
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Glioblastoma, Secondary gliosarcoma, Recurrence
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